2014 Fiscal Year Final Research Report
Determining GLP-1 responsive genes involved in the regulation of appetite and energy metabolism
| Project/Area Number |
25670429
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | GLP-1受容体 / ＦＧＦ２１ |
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| Outline of Final Research Achievements |
Here we show that systemic administration of liraglutide, a long-acting human glucagon-like peptide-1 (GLP-1) analog, significantly decreased food
intake, body weight, and blood glucose levels at 24 h after its administration in individually housed KKAy mice. In addition, the systemic administration of liraglutide significantly increased plasma fibroblast growth factor (Fgf) 21 levels associated with increases in the expression of hepatic Fgf21, while having no effects on the expression of Fgf21 in white adipose tissue. Despite remarkably increased plasma active GLP-1 levels, the ingestion of alogliptin, a selective dipeptidyl peptidase-4 inhibitor, had no effects on food intake, body weight, blood glucose levels, and plasma Fgf21 levels. These findings suggest that systemic administration of liraglutide induces hepatic Fgf21 production and suppresses the social isolation-induced obesity and diabetes independently of insulin, glucagon, and active GLP-1 in KKAy mice.
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| Free Research Field |
代謝学
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