2014 Fiscal Year Final Research Report
Elucidation of the inflammasome regulatory mechanism by fatty acid elongase Elovl6
| Project/Area Number |
25670430
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Akimitsu 筑波大学, 医学医療系, 准教授 (70344893)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 脂肪酸 / 炎症 / インフラマソーム |
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| Outline of Final Research Achievements |
We analyzed the role of fatty acid elongase Elovl6 in the regulation of NLRP3 inflammasome. Saturated fatty acid palmitate-induced NLRP3 inflammasome activation was suppressed in hepatocytes and macrophages of Elovl6KO mice as compared with those of wild-type mice. Moreover, we observed that one of the regulatory factors of NLRP3 inflammasome was suppressed in hepatocytes and macrophages of Elovl6KO mice. Our findings suggest that inhibition of Elovl6 could be a new therapeutic approach for ameliorating metabolic inflammation through suppression of NLRP3 inflammasome.
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| Free Research Field |
代謝内分泌学
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