2014 Fiscal Year Final Research Report
Analysis of congenital endocrine disorders by chromatin structure changes
| Project/Area Number |
25670440
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | クロマチン構造変換 / 転写制御 / GSTA / 3Cアッセイ / SF-1 |
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| Outline of Final Research Achievements |
Transcriptional regulation of new SF-1 target genes, glutathione S transferase A family, were analyzed by chromatin structural changes such as 3C assays. We found that all GSTA family genes were under control by SF-1. These observations indicate that clustering GSTA family genes were organized by three dimensional chromatin structure induced by SF-1 binding to the gene locus. Together with the observations that gene products from GSTA1 and GSTA3 work as steroid isomerases, these SF-1 target genes would cause congenital steroid hormone deficient syndromes based on the chromatin structure changes.
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| Free Research Field |
内分泌学
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