Origin of inflammatory cells constituting malignant lymphoma tissue

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670444
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: University of Tsukuba
• Principal Investigator: CHIBA Shigeru 筑波大学, 医学医療系, 教授 (60212049)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 悪性リンパ腫 / 炎症細胞 / 遺伝子変異

Outline of Final Research Achievements

Inflammatory cells participate in the malignant lymphoma tissues together with tumor cells. In this research, we demonstrated that tumor cells and inflammatory cells in the malignant lymphoma tissues have a common ancestor cell. In detail, a single hematopoietic progenitor cell becomes a “cancer-preparing cell” by sequentially acquiring gene mutations, which eventually produces tumor cells and inflammatory cells. This is the first to prove such a concept.

Free Research Field

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