Clinical significance of anti-disulfide isomerase based on the AIRE research

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670461
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Kyushu University
• Principal Investigator: NAGAFUCHI Seiho 九州大学, 医学(系)研究科(研究院), 教授 (00150441)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 自己免疫調節遺伝子 / 自己抗体 / 自己免疫疾患 / Disulfide Isomerase

Outline of Final Research Achievements

Since we found auto antigen in Aire knockout mice associated with autoimmune pancreatitis was disulfide isomerase (DI), we conducted human anti-DI antibody detection study in various autoimmune diseases, including autoimmune pancreatitis, gastritis, primary biliary cirrhosis, sjogren syndrome and autoimmune retinitis. We developed western blot system as well as enzyme linked immunosorbent assay. we screened 200 cases, however, we could not detect any autoantibody. It was suggested improvement of assay system to detect anti-DI is essentially important and the study should be continued to solve the problems.

Free Research Field

臨床内科学