A basic study on combination vaccines of rotavirus and norovirus

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670479
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Nihon University
• Principal Investigator: USHIJIMA Hiroshi 日本大学, 医学部, 客員教授 (10091068)
• Co-Investigator(Renkei-kenkyūsha): OKITSU Shoko 東京大学, 医学系研究科, 客員研究員 (10082215) ; TAKANASHI Sayaka 東京大学, 医学系研究科, 助教 (20645709) ; MACHIDA Sanae 埼玉医科大学, 医学部, 助教 (00219362)
• Research Collaborator: KHAMRIN Pattara 日本大学, 医学部, 客員研究員 ; THONPRACHUM Aksara 日本学術振興会, 日本大学医学部, 外国人特別研究員 ; NOMURA Akiko イムノプローブ株式会社, 研究員 ; HAYAKAWA Satoshi 日本大学, 医学部, 教授
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ワクチン / ロタウイルス / ノロウイルス / 混合ワクチン / マウスモデル / 経口接種

Outline of Final Research Achievements

Basic experiments was done for combination oral vaccines of rotavirus and norovirus. Rotavirus vaccine strain (Rotarix) and artificially produced rotavirus protein (VP6) were used for rotavirus vaccines. Virus like particles were used for norovirus vaccine. Elevation of viral antibodies was the same as the individual vaccine and a synergistic effect of combination vaccines were not recognized. Rotavirus gastroenteritis (diarrhea) was induced into newborn mice by oral vaccination. However norovirus gastroenteritis was not induced in newborn mice.
Combination vaccines are expected to develop in reference to the cases of rotavirus vaccination and the cases of recurrent norovirus infection.

Free Research Field

ワクチン学