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2013 Fiscal Year Annual Research Report

基底膜による皮膚細菌叢の制御機構の解明

Research Project

Project/Area Number 25670494
Research InstitutionHokkaido University

Principal Investigator

清水 宏  北海道大学, 医学(系)研究科(研究院), 教授 (00146672)

Co-Investigator(Kenkyū-buntansha) 西江 渉  北海道大学, 大学病院, 講師 (20443955)
夏賀 健  北海道大学, 大学病院, 助教 (70645457)
Project Period (FY) 2013-04-01 – 2014-03-31
Keywords表皮水疱症 / 皮膚基底膜 / 細菌叢
Research Abstract

皮膚基底膜は、これまで表皮と真皮の接着を担うという点を中心に研究されてきた。しかしながら、近年、皮膚基底膜が幹細胞のニッチとなっていることが明らかになりつつあるなど、表皮と真皮の接着にとどまらない基底膜の役割が明らかになりつつある。申請者とそのグループは、皮膚基底膜が皮膚の細菌叢に対する防御機構を担っているのではないかという仮説をもとに、本研究は遂行した。本研究の成果は、皮膚基底膜蛋白が欠損して生じる表皮水疱症患者における皮膚細菌感染症の生じる機序を知る上で、非常に重要な実験系である。
実施計画に予定されていたとおり、皮膚基底膜蛋白欠損マウスとして表皮基底膜領域のヘミデスモソームに発現する17型コラーゲン(COL17)ノックアウト(KO)マウスとその同胞となるCOL17KOヘテロマウスの皮膚について、皮膚細菌叢を解析した。P1の段階では、ヘテロマウスのほうで皮膚細菌量が多く、P4では両者で皮膚細菌量が同等であることが確認された。Fluorescent in situ hybridizationを用いた皮膚細菌叢の可視化実験では、COL17KOマウス、COL17KOヘテロマウスともに主に表皮の角層において細菌叢が確認された。陰性コントロールとして用いた、皮膚に存在しない真菌のプローブではシグナルを認めなかった。今後は、長期生存するCOL17KOマウスの皮膚や表皮水疱症患者皮膚を用いてさらに皮膚細菌叢の解析を進める必要がある。

  • Research Products

    (59 results)

All 2014 2013 Other

All Journal Article (53 results) (of which Peer Reviewed: 53 results) Presentation (4 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] Long-term Follow-up of Cultured Epidermal Autograft in a Patient with Recessive Dystrophic Epidermolysis Bullosa2014

    • Author(s)
      Shinkuma S, Sawamura D, Fujita Y, Kawasaki H, Nakamura H, Inoie M, Nishie W, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 94 Pages: 98-99

    • DOI

      10.2340/00015555-1592

    • Peer Reviewed
  • [Journal Article] A novel NCSTN mutation alone may be insufficient for the development of familial hidradenitis suppurativa2014

    • Author(s)
      Nomura Y, Nomura T, Suzuki S, Takeda M, Mizuno O, Ohguchi Y, Abe R, Murata Y, Shimizu H
    • Journal Title

      J Dermatol Sci

      Volume: 74 Pages: 180-182

    • DOI

      10.1016/j.jdermsci.2014.01.013

    • Peer Reviewed
  • [Journal Article] Repeated skin sampling and prolonged incubation period identified cutaneous Mycobacterium chelonae infection on the face in an immunocompetent man2014

    • Author(s)
      Muramatsu K, Nomura T, Ito T, Hamade Y, Hirata Y, Fujita Y, Abe R, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: 170 Pages: 471-473

    • DOI

      10.1111/bjd.12638

    • Peer Reviewed
  • [Journal Article] Characteristic findings of handprint and dermoscopy in reticulate acropigmentation of Kitamura2014

    • Author(s)
      Koguchi H, Ujiie H, Aoyagi S, Osawa R, Shimizu H
    • Journal Title

      Clin Exp Dermatol

      Volume: 39 Pages: 85-87

    • DOI

      10.1111/ced.12191

    • Peer Reviewed
  • [Journal Article] Localized cutaneous amyloidosis associated with poikilodermatous mycosis fungoides2014

    • Author(s)
      Izumi K, Arita K, Horie K, Hoshina D, Shimizu H
    • Journal Title

      Acta Dermato-Venereologica

      Volume: 94 Pages: 225-226

    • DOI

      10.2340/00015555-1657

    • Peer Reviewed
  • [Journal Article] Tubular Spitz Naevus Mimicking Eccrine Spiradenoma2014

    • Author(s)
      Fujita Y, Aoyagi S, Tsujiwaki M, Homma E, Ujiie H, Fujita H, Hatanaka KC, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 94 Pages: 114-115

    • DOI

      10.2340/00015555-1641

    • Peer Reviewed
  • [Journal Article] Epidermal Wnt/beta-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors2014

    • Author(s)
      Donati G, Proserpio V, Lichtenberger BM, Natsuga K, Sinclair R, Fujiwara H, Watt FM
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 111 Pages: E1501-1509

    • DOI

      10.1073/pnas.1312880111

    • Peer Reviewed
  • [Journal Article] Technique for histological control of surgical margins in lip cancer2014

    • Author(s)
      Aoyagi S, Hata H, Homma E, Shimizu H
    • Journal Title

      J Dermatol

      Volume: 41 Pages: 316-318

    • DOI

      10.1111/1346-8138.12424

    • Peer Reviewed
  • [Journal Article] Intraoperative use of spectroscopic detection of protoporphyrin IX from oral 5-aminolevulinic acid on basal cell carcinoma and squamous cell carcinoma during Mohs surgery2014

    • Author(s)
      Aoyagi S, Hata H, Homma E, Horie K, Shimizu H
    • Journal Title

      Lasers Surg Med

      Volume: 46 Pages: 132-139

    • DOI

      10.1002/lsm.22208

    • Peer Reviewed
  • [Journal Article] Kindler Syndrome with Severe Intestinal Involvement: A 31-year Follow-up2014

    • Author(s)
      Shimizu S, Nishie W, Tsuchiya K, Inokuma D, Koguchi-Yoshioka H, Kikuchi K, Motoya S, Nakamura H, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 印刷中 Pages: 印刷中

    • DOI

      10.2340/00015555-1696

    • Peer Reviewed
  • [Journal Article] Epidermal barriers2014

    • Author(s)
      Natsuga K
    • Journal Title

      Cold Spring Harb Perspect Med

      Volume: 4 Pages: a018218

    • DOI

      10.1101/cshperspect.a018218

    • Peer Reviewed
  • [Journal Article] Inherited epidermolysis bullosa: Updated recommendations on diagnosis and classification2014

    • Author(s)
      Fine JD, Bruckner-Tuderman L, Eady RA, Bauer EA, Bauer JW, Has C, Heagerty A, Hintner H, Hovnanian A, Jonkman MF, Leigh I, Marinkovich MP, Martinez AE, McGrath JA, Mellerio JE, Moss C, Murrell DF, Shimizu H, Uitto J, Woodley D, Zambruno G
    • Journal Title

      J Am Acad Dermatol

      Volume: 印刷中 Pages: 印刷中

    • DOI

      10.1016/j.jaad.2014.01.903

    • Peer Reviewed
  • [Journal Article] Recurrent course and CD30 expression of atypical T lymphocytes distinguish lymphomatoid papulosis type D from primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma2014

    • Author(s)
      Tsujiwaki M, Abe R, Ohguchi Y, Hoshina D, Murata J, Fujita Y, Nomura T, Ambo M, Shimizu H
    • Journal Title

      Acta Dermato Venereol

      Volume: 印刷中 Pages: 印刷中

    • DOI

      10.2340/00015555-1806

    • Peer Reviewed
  • [Journal Article] Nanoparticle albumin-bound paclitaxel can be useful agent to advanced primary mucinous carcinoma of the skin2014

    • Author(s)
      Ohguchi Y, Nomura T, Suzuki S, Mizuno O, Nomura Y, Nomoto-Hasebe I, Okamoto H, Sandilands A, Akiyama M, McLean WH, Shimizu H
    • Journal Title

      Dermatologic therapy

      Volume: 印刷中 Pages: 印刷中

    • Peer Reviewed
  • [Journal Article] Punctate palmoplantar keratoderma type 1: a novel AAGAB mutation and efficacy of etretinate2014

    • Author(s)
      Nomura T, Yoneta A, Pohler E, Suzuki S, Osawa R, Mizuno O, Ohguchi Y, Nomura Y, Yamashita T, McLean W, Shimizu H
    • Journal Title

      Acta Dermato Venereol

      Volume: 印刷中 Pages: 印刷中

    • DOI

      10.2340/00015555-1832

    • Peer Reviewed
  • [Journal Article] Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma2014

    • Author(s)
      Ito T, Nomura T, Fujita Y, Abe R, Shimizu H
    • Journal Title

      J Am Acad Dermatol

      Volume: 印刷中 Pages: 印刷中

    • Peer Reviewed
  • [Journal Article] Nanoparticle albumin-bound paclitaxel can be useful agent to advanced primary mucinous carcinoma of the skin2014

    • Author(s)
      Homma E, Hata H, Aoyagi S, Shimizu H
    • Journal Title

      Dermatologic therapy

      Volume: 印刷中 Pages: 印刷中

    • Peer Reviewed
  • [Journal Article] Ultrasound B-mode and Elastographic Findings of Angiomatoid Fibrous Histiocytoma2014

    • Author(s)
      Hata H, Natsuga K, Homma E, Aoyagi S, Shimizu H
    • Journal Title

      Clin Exp Dermatol

      Volume: 印刷中 Pages: 印刷中

    • Peer Reviewed
  • [Journal Article] Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility2014

    • Author(s)
      Cipolat S, Hoste E, Natsuga K, Quist S, Watt FM
    • Journal Title

      eLife

      Volume: 印刷中 Pages: 印刷中

    • Peer Reviewed
  • [Journal Article] Sweet's syndrome presenting with vegetative nodules on the hands: relationship to neutrophilic dermatosis of the dorsal hands2014

    • Author(s)
      Mizuno O, Yanagi T, Baba K, Yamane N, Inokuma D, Ito K, Akiyama M, Shimizu H
    • Journal Title

      Int J Dermatol

      Volume: 53 Pages: e46-48

    • DOI

      10.1111/j.1365-4632.2011.05352.x

    • Peer Reviewed
  • [Journal Article] Bilateral axillary Paget's disease: diagnostic pitfalls of dermoscopic features2014

    • Author(s)
      Hirata Y, Aoyagi S, Mizuno O, Homma E, Hata H, Shimizu H
    • Journal Title

      Int J Dermatol

      Volume: 53 Pages: e126-127

    • DOI

      10.1111/j.1365-4632.2012.05605.x

    • Peer Reviewed
  • [Journal Article] Minute reddish patch of extramammary Paget's disease with notable lymph node metastases2013

    • Author(s)
      Hata H, Aoyagi S, Baba K, Homma E, Shimizu H
    • Journal Title

      Int J Dermatol

      Volume: 52 Pages: 1593-1595

    • DOI

      10.1111/j.1365-4632.2011.05312

    • Peer Reviewed
  • [Journal Article] Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experiment2013

    • Author(s)
      Hoshina D, Abe R, Yoshioka N, Saito N, Hata H, Fujita Y, Aoyagi S, Shimizu H
    • Journal Title

      J Dermatol Sci

      Volume: 70 Pages: 116-12

    • DOI

      10.1016/j.jdermsci.2013.02.008

    • Peer Reviewed
  • [Journal Article] Dermoscopy of pseudoxanthoma elasticum-like papillary dermal elastolysis2013

    • Author(s)
      Ito T, Fujita Y, Nomura T, Abe R, Shimizu H
    • Journal Title

      J Am Acad Dermatol

      Volume: 69 Pages: e202-203

    • DOI

      10.1016/j.jaad.2013.04.059

    • Peer Reviewed
  • [Journal Article] Infantile eczema caused by formula milk2013

    • Author(s)
      Ito T, Nishie W, Fujita Y, Abe R, Shimizu H
    • Journal Title

      Lancet

      Volume: 381 Pages: 1958

    • DOI

      10.1016/S0140-6736(13)60684-4

    • Peer Reviewed
  • [Journal Article] Intractable erythematous plaques on the hands : palmoplantar eosinophilic pustular folliculitis2013

    • Author(s)
      Izumi K, Yanagi T, Akiyama M, Moriuchi R, Arita K, Shimizu H
    • Journal Title

      Int J Dermatol

      Volume: 52 Pages: 1274-1275

    • DOI

      10.1111/j.1365-4632.2011.05139.x

    • Peer Reviewed
  • [Journal Article] An Erythematous Plaque on the Breast : A Quiz2013

    • Author(s)
      Koguchi H, Arita K, Nakazato S, Moriuchi R, Yamane N, Shinkuma S, Matsumura K, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 763-765

    • DOI

      10.2340/00015555-1527

    • Peer Reviewed
  • [Journal Article] Confluent and reticulated papillomatosis associated with 15q tetrasomy syndrome2013

    • Author(s)
      Koguchi H, Ujiie H, Aoyagi S, Osawa R, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 202-203

    • DOI

      10.2340/00015555-1437

    • Peer Reviewed
  • [Journal Article] A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa2013

    • Author(s)
      Nomura Y, Nomura T, Sakai K, Sasaki K, Ohguchi Y, Mizuno O, Hata H, Aoyagi S, Abe R, Itaya Y, Akiyama M, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: 168 Pages: 206-209

    • DOI

      10.1111/j.1365-2133.2012.11174.x

    • Peer Reviewed
  • [Journal Article] Wells' Syndrome Associated with Chronic Myeloid Leukaemia2013

    • Author(s)
      Nakazato S, Fujita Y, Hamade Y, Nemoto-Hasebe I, Sugita J, Nishie W, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 375-376

    • DOI

      10.2340/00015555-1483

    • Peer Reviewed
  • [Journal Article] c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis2013

    • Author(s)
      Cottle DL, Kretzschmar K, Schweiger PJ, Quist SR, Gollnick HP, Natsuga K, Aoyagi S, Watt FM
    • Journal Title

      Cell Rep

      Volume: 3 Pages: 427-441

    • DOI

      10.1016/j.celrep.2013.01.013

    • Peer Reviewed
  • [Journal Article] A method for intravital monitoring of human cells using a far-red luminescent probe in graft-versus-host disease model mice2013

    • Author(s)
      Qiao H, Abe R, Saito N, Fujita Y, Hayashi-Ujiie I, Wang G, Haga S, Wu C, Ohmiya Y, Ozaki M, Shimizu H
    • Journal Title

      J Invest Dermatol

      Volume: 133 Pages: 841-84

    • DOI

      10.1038/jid.2012.345

    • Peer Reviewed
  • [Journal Article] Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients2013

    • Author(s)
      Saito N, Yoshioka N, Abe R, Qiao H, Fujita Y, Hoshina D, Suto A, Kase S, Kitaichi N, Ozaki M, Shimizu H
    • Journal Title

      J Allergy Clin Immunol

      Volume: 131 Pages: 434-441, e431-439

    • DOI

      10.1016/j.jaci.2012.09.014

    • Peer Reviewed
  • [Journal Article] Cutaneous Manifestations of Helicobacter cinaedi Infection2013

    • Author(s)
      Shimizu S, Inokuma D, Watanabe M, Sakai T, Yamamoto S, Tsuchiya K, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 165-167

    • DOI

      10.2340/00015555-1396

    • Peer Reviewed
  • [Journal Article] A Novel Keratin 5 Mutation in an African Family with Epidermolysis Bullosa Simplex Indicates the Importance of the Amino Acid Located at the Boundary Site Between the H1 and Coil 1A Domains2013

    • Author(s)
      Shinkuma S, Nishie W, Jacyk WK, Natsuga K, Ujiie H, Nakamura H, Akiyama M, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 585-587

    • DOI

      10.2340/00015555-1538

    • Peer Reviewed
  • [Journal Article] Prevalent founder mutation c.736T>A of LIPH in autosomal recessive woolly hair of Japanese leads to variable severity of hypotrichosis in adulthood2013

    • Author(s)
      Tanahashi K, Sugiura K, Takeichi T, Takama H, Shinkuma S, Shimizu H, Akiyama M
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 27 Pages: 1182-1184

    • DOI

      10.1111/j.1468-3083.2012.04526.x

    • Peer Reviewed
  • [Journal Article] LC-MS/MS analysis of canine lipoproteins fractionated using the ultracentrifugation-precipitation method2013

    • Author(s)
      Suto A, Yamasaki M, Takasaki Y, Fujita Y, Abe R, Shimizu H, Ohta H, Takiguchi M
    • Journal Title

      J Vet Med Sci

      Volume: 75 Pages: 1471-1477

    • Peer Reviewed
  • [Journal Article] Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain Fatty Acid production2013

    • Author(s)
      Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A
    • Journal Title

      Mol Cell Biol

      Volume: 33 Pages: 2787-2796

    • DOI

      10.1128/MCB.00192-13

    • Peer Reviewed
  • [Journal Article] Indomethacin for Refractory Infantile Eosinophilic Pustular Folliculitis2013

    • Author(s)
      Toyonaga E, Abe R, Moriuchi R, Ito K, Abe Y, Shimizu H
    • Journal Title

      JAMA Dermatol

      Volume: 149 Pages: 367-368

    • DOI

      10.1001/2013.jamadermatol.591

    • Peer Reviewed
  • [Journal Article] Pagetoid dyskeratosis with parallel ridge pattern under dermoscopy2013

    • Author(s)
      Toyonaga E, Inokuma D, Abe Y, Abe R, Shimizu H
    • Journal Title

      JAMA Dermatol

      Volume: 149 Pages: 109-111

    • DOI

      10.1001/archdermatol.2012.3201

    • Peer Reviewed
  • [Journal Article] Disturbed balance in three subpopulations of CD4(+)Foxp3(+) regulatory T cells in Stevens-Johnson syndrome and toxic epidermal necrolysis patients2013

    • Author(s)
      Yoshioka N, Suto A, Abe R, Saito N, Murata J, Hayashi-Ujiie I, Hoshina D, Fujita Y, Shimizu H
    • Journal Title

      Clin Immunol

      Volume: 148 Pages: 89-91

    • DOI

      10.1016/j.clim.2013.04.002

    • Peer Reviewed
  • [Journal Article] Hallopeau-Siemens dystrophic epidermolysis bullosa due to homozygous 5818delC mutation in the COL7A gene2013

    • Author(s)
      Koshida S, Tsukamura A, Yanagi T, Nakahara S, Takeuchi Y, Kato T, Tanaka T, Nakano H, Shimizu H
    • Journal Title

      Pediatr Int

      Volume: 55 Pages: 234-237

    • DOI

      10.1111/j.1442-200X.2012.03638.x

    • Peer Reviewed
  • [Journal Article] Coexistence case of bullous pemphigoid and pemphigus foliaceus2013

    • Author(s)
      Tsujiwaki M, Abe R, Nomura Y, Nishimura M, Hoshina D, Shinkuma S, Natsuga K, Ujiie H, Arita K, Shimizu H
    • Journal Title

      Eur J Dermatol

      Volume: 23 Pages: 552-553

    • DOI

      10.1684/ejd.2013.2084

    • Peer Reviewed
  • [Journal Article] Linear congenital molluscum contagiosum on the coccygeal region2013

    • Author(s)
      Ujiie H, Aoyagi S, Hirata Y, Osawa R, Shimizu H
    • Journal Title

      Pediatr Dermatol

      Volume: 30 Pages: e83-84

    • DOI

      10.1111/pde.12035

    • Peer Reviewed
  • [Journal Article] Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis

    • Author(s)
      Mizuno O, Nomura T, Suzuki S, Takeda M, Ohguchi Y, Fujita Y, Nishie W, Sugiura K, Akiyama M, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: (in press)

    • DOI

      10.1111/bjd.13076

    • Peer Reviewed
  • [Journal Article] Loss-of-function mutations in the gene encoding filaggrin underlie a Japanese family with food-dependent exercise-induced anaphylaxis

    • Author(s)
      Mizuno O, Nomura T, Ohguchi Y, Suzuki S, Nomura Y, Hamade Y, Hoshina D, Sandilands A, Akiyama M, McLean WH, Abe R, Shimizu H
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: (in press)

    • DOI

      10.1111/jdv.12441

    • Peer Reviewed
  • [Journal Article] Comprehensive screening for a complete set of Japanese-population-specific filaggrin gene mutations

    • Author(s)
      Kono M, Nomura T, Ohguchi Y, Mizuno O, Suzuki S, Tsujiuchi H, Hamajima M, McLean W, Shimizu H, Akiyama M
    • Journal Title

      Allergy

      Volume: (in press)

    • DOI

      10.1111/all.12369

    • Peer Reviewed
  • [Journal Article] Paper-Based ELISA for the Detection of Autoimmune Antibodies in Body Fluid-The Case of Bullous Pemphigoid

    • Author(s)
      Hsu CK, Huang HY, Chen WR, Nishie W, Ujiie H, Natsuga K, Fan ST, Wang HK, Lee JY, Tsai WL, Shimizu H, Cheng CM
    • Journal Title

      Anal Chem

      Volume: (in press)

    • DOI

      10.1021/ac500835k

    • Peer Reviewed
  • [Journal Article] Solitary tumor on the neck

    • Author(s)
      Horie K, Abe R, Murata J, Nomura T, Shimizu H
    • Journal Title

      Acta Dermato Venereol

      Volume: (in press)

    • DOI

      10.2340/00015555-1792

    • Peer Reviewed
  • [Journal Article] Primary mucinous carcinoma of the skin with in-transit metastasis

    • Author(s)
      Homma E, Hata H, Aoyagi S, Shimizu H
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: (in press)

    • DOI

      10.1111/jdv.12533

    • Peer Reviewed
  • [Journal Article] MUC5AC expression correlates with invasiveness and progression of extramammary Paget's disease

    • Author(s)
      Hata H, Abe R, Hoshina D, Saito N, Homma E, Aoyagi S, Shimizu H
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: (in press)

    • DOI

      10.1111/ced.12314

    • Peer Reviewed
  • [Journal Article] Two cases of pseudolymphoma on the lips

    • Author(s)
      Haga N, Nishie W, Hata H, Miyauchi T, Muramatsu K, Kitamura S, Osawa R, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: (in press)

    • DOI

      10.1111/bjd.12837

    • Peer Reviewed
  • [Journal Article] Dermoscopic Features of Plasma Cell Cheilitis and Actinic Cheilitis

    • Author(s)
      Ito T, Natsuga K, Tanimura S, Aoyagi S, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: (in press)

    • DOI

      10.2340/00015555-1795

    • Peer Reviewed
  • [Presentation] Pathogenetic mechanisms in autoimmune skin fragility2013

    • Author(s)
      Natsuga K
    • Organizer
      The 40th Annual Meeting of Society for Cutaneous Ultrastructure Research
    • Place of Presentation
      Castellani Parkhotel Salzburg (Austria)
    • Year and Date
      20130512-20130514
    • Invited
  • [Presentation] Skin barrier defect allows more abundant microbiota in skin and induces skin inflammation and the expression of antimicrobial peptides independently of microbiota2013

    • Author(s)
      Natsuga K, Cipolat S, Watt FM
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh International Conference Centre (UK)
    • Year and Date
      20130508-20130511
  • [Presentation] Detection of pathological cleavage sites and neoepitopes on collagen XVII, a major autoantigen for bullous pemphigoid2013

    • Author(s)
      Nishie W, Ujiie H, Izumi K, Shimizu H
    • Organizer
      The International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh International Conference Centre (UK)
    • Year and Date
      20130508-20130511
  • [Presentation] Shedding of the type VII collagen2013

    • Author(s)
      Nishie W
    • Organizer
      The International Pre IID 2013 Meeting on Autoimmune Bullous Diseases
    • Place of Presentation
      Audimax AM 3 (Germany)
    • Year and Date
      20130506-20130507
    • Invited
  • [Book] Current Genetics in Dermatology2013

    • Author(s)
      Natsuga K
    • Total Pages
      16
    • Publisher
      INTECH
  • [Book] Methods Mol Biol2013

    • Author(s)
      Nishie W
    • Total Pages
      7
    • Publisher
      Springer

URL: 

Published: 2015-05-28  

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