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2013 Fiscal Year Final Research Report

Modulation of skin microbiota through basememt membrane

Research Project

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Project/Area Number 25670494
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

SHIMIZU Hiroshi  北海道大学, 医学(系)研究科(研究院), 教授 (00146672)

Co-Investigator(Kenkyū-buntansha) NISHIE Wataru  北海道大学, 大学病院, 講師 (20443955)
NATSUGA Ken  北海道大学, 大学病院, 助教 (70645457)
Project Period (FY) 2013-04-01 – 2014-03-31
Keywords皮膚細菌叢
Research Abstract

Skin microbiota of mice deficient for skin basement membrane protein (BMZ-deficient mice) were analyzed. At P1, BMZ-deficient mice had less abundant skin microbiota compared with the control group mice while the quantity of skin bacteria was comparable between BMZ-deficient mice and the control mice at P4. Visualization of skin microbiota using FISH methods revealed that bacterial signals were located mainly in the cornified layers of BMZ-deficient mice and the control mice. The specificity of the probe to detect bacterial signals was confirmed by the negative FISH signals using a probe reacting with fungal species which are not found in skin. Further analyses will be done on microbiota of adult BMZ-deficient mice skin and human epidermolysis bullosa patients' skin.

  • Research Products

    (57 results)

All 2014 2013 Other

All Journal Article (50 results) (of which Peer Reviewed: 50 results) Presentation (4 results) (of which Invited: 2 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Inherited epidermolysis bullosa : Updated recommendations on diagnosis and classification2014

    • Author(s)
      Fine JD, Bruckner-Tuderman L, Eady RA, Bauer EA, Bauer JW, Has C, Heagerty A, Hintner H, Hovnanian A, Jonkman MF, Leigh I, Marinkovich MP, Martinez AE, McGrath JA, Mellerio JE, Moss C, Murrell DF, Shimizu H, Uitto J, Woodley D, Zambruno G
    • Journal Title

      J Am Acad Dermatol

      Volume: (in press)

    • DOI

      10.1016/j.jaad.2014.01.903

    • Peer Reviewed
  • [Journal Article] Long-term Follow-up of Cultured Epidermal Autograft in a Patient with Recessive Dystrophic Epidermolysis Bullosa2014

    • Author(s)
      Shinkuma S, Sawamura D, Fujita Y, Kawasaki H, Nakamura H, Inoie M, Nishie W, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 94 Pages: 98-99

    • DOI

      10.2340/00015555-1592

    • Peer Reviewed
  • [Journal Article] Kindler Syndrome with Severe Intestinal Involvement : A 31-year Follow-up2014

    • Author(s)
      Shimizu S, Nishie W, Tsuchiya K, Inokuma D, Koguchi-Yoshioka H, Kikuchi K, Motoya S, Nakamura H, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 94 Pages: 351-352

    • DOI

      10.2340/00015555-1696

    • Peer Reviewed
  • [Journal Article] A novel NCSTN mutation alone may be insufficient for the development of familial hidradenitis suppurativa2014

    • Author(s)
      Nomura Y, Nomura T, Suzuki S, Takeda M, Mizuno O, Ohguchi Y, Abe R, Murata Y, Shimizu H
    • Journal Title

      J Dermatol Sci

      Volume: 74 Pages: 180-182

    • DOI

      10.1016/j.jdermsci.2014.01.013

    • Peer Reviewed
  • [Journal Article] Repeated skin sampling and prolonged incubation period identified cutaneous Mycobacterium chelonae infection on the face in an immunocompetent man2014

    • Author(s)
      Muramatsu K, Nomura T, Ito T, Hamade Y, Hirata Y, Fujita Y, Abe R, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: 170 Pages: 471-473

    • DOI

      10.1111/bjd.12638

    • Peer Reviewed
  • [Journal Article] Sweet's syndrome presenting with vegetative nodules on the hands : relationship to neutrophilic dermatosis of the dorsal hands2014

    • Author(s)
      Mizuno O, Yanagi T, Baba K, Yamane N, Inokuma D, Ito K, Akiyama M, Shimizu H
    • Journal Title

      Int J Dermatol

      Volume: 53 Pages: e46-48

    • DOI

      10.1111/j.1365-4632.2011.05352.x

    • Peer Reviewed
  • [Journal Article] Characteristic findings of handprint and dermoscopy in reticulate acropigmentation of Kitamura2014

    • Author(s)
      Koguchi H, Ujiie H, Aoyagi S, Osawa R, Shimizu H
    • Journal Title

      Clin Exp Dermatol

      Volume: 39 Pages: 85-87

    • DOI

      10.1111/ced.12191

    • Peer Reviewed
  • [Journal Article] Localized cutaneous amyloidosis associated with poikilodermatous mycosis fungoides2014

    • Author(s)
      Izumi K, Arita K, Horie K, Hoshina D, Shimizu H
    • Journal Title

      Acta Dermato-Venereologica

      Volume: 94 Pages: 225-226

    • DOI

      10.2340/00015555-1657

    • Peer Reviewed
  • [Journal Article] Bilateral axillary Paget's disease : diagnostic pitfalls of dermoscopic features.2014

    • Author(s)
      Hirata Y, Aoyagi S, Mizuno O, Homma E, Hata H, Shimizu H
    • Journal Title

      Int J Dermatol

      Volume: 53 Pages: e126-127

    • DOI

      10.1111/j.1365-4632.2012.05605.x

    • Peer Reviewed
  • [Journal Article] Tubular Spitz Naevus Mimicking Eccrine Spiradenoma2014

    • Author(s)
      Fujita Y, Aoyagi S, Tsujiwaki M, Homma E, Ujiie H, Fujita H, Hatanaka KC, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 94 Pages: 114-115

    • DOI

      10.2340/00015555-1641

    • Peer Reviewed
  • [Journal Article] Epidermal Wnt/beta-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors2014

    • Author(s)
      Donati G, Proserpio V, Lichtenberger BM, Natsuga K, Sinclair R, Fujiwara H, Watt FM
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 111 Pages: E1501-1509

    • DOI

      10.1073/pnas.1312880111

    • Peer Reviewed
  • [Journal Article] Technique for histological control of surgical margins in lip cancer2014

    • Author(s)
      Aoyagi S, Hata H, Homma E, Shimizu H
    • Journal Title

      J Dermatol

      Volume: 41 Pages: 316-318

    • DOI

      10.1111/1346-8138.12424

    • Peer Reviewed
  • [Journal Article] Intraoperative use of spectroscopic detection of protoporphyrin IX from oral 5-aminolevulinic acid on basal cell carcinoma and squamous cell carcinoma during Mohs surgery2014

    • Author(s)
      Aoyagi S, Hata H, Homma E, Horie K, Shimizu H
    • Journal Title

      Lasers Surg Med

      Volume: 46 Pages: 132-139

    • DOI

      10.1002/lsm.22208

    • Peer Reviewed
  • [Journal Article] Epidermal Barriers2014

    • Author(s)
      Natsuga K
    • Journal Title

      Cold Spring Harb Perspect Med

      Volume: 4 Pages: a018218

    • DOI

      10.1101/cshperspect.a018218

    • Peer Reviewed
  • [Journal Article] Minute reddish patch of extramammary Paget's disease with notable lymph node metastases2013

    • Author(s)
      Hata H, Aoyagi S, Baba K, Homma E, Shimizu H
    • Journal Title

      Int J Dermatol

      Volume: 52 Pages: 1593-1595

    • DOI

      10.1111/j.1365-4632.2011.05312

    • Peer Reviewed
  • [Journal Article] Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experiment2013

    • Author(s)
      Hoshina D, Abe R, Yoshioka N, Saito N, Hata H, Fujita Y, Aoyagi S, Shimizu H
    • Journal Title

      J Dermatol Sci

      Volume: 70 Pages: 116-12

    • DOI

      10.1016/j.jdermsci.2013.02.008

    • Peer Reviewed
  • [Journal Article] Dermoscopy of pseudoxanthoma elasticum-like papillary dermal elastolysis2013

    • Author(s)
      Ito T, Fujita Y, Nomura T, Abe R, Shimizu H
    • Journal Title

      J Am Acad Dermatol

      Volume: 69 Pages: e202-203

    • DOI

      10.1016/j.jaad.2013.04.059

    • Peer Reviewed
  • [Journal Article] Infantile eczema caused by formula milk2013

    • Author(s)
      Ito T, Nishie W, Fujita Y, Abe R, Shimizu H
    • Journal Title

      Lancet

      Volume: 381 Pages: 1958

    • DOI

      10.1016/S0140-6736(13)60684-4

    • Peer Reviewed
  • [Journal Article] Intractable erythematous plaques on the hands : palmoplantar eosinophilic pustular folliculitis2013

    • Author(s)
      Izumi K, Yanagi T, Akiyama M, Moriuchi R, Arita K, Shimizu H
    • Journal Title

      Int J Dermatol

      Volume: 52 Pages: 1274-1275

    • DOI

      10.1111/j.1365-4632.2011.05139.x

    • Peer Reviewed
  • [Journal Article] An Erythematous Plaque on the Breast : A Quiz2013

    • Author(s)
      Koguchi H, Arita K, Nakazato S, Moriuchi R, Yamane N, Shinkuma S, Matsumura K, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 763-765

    • DOI

      10.2340/00015555-1527

    • Peer Reviewed
  • [Journal Article] Confluent and reticulated papillomatosis associated with 15q tetrasomy syndrome2013

    • Author(s)
      Koguchi H, Ujiie H, Aoyagi S, Osawa R, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 202-203

    • DOI

      10.2340/00015555-1437

    • Peer Reviewed
  • [Journal Article] A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa2013

    • Author(s)
      Nomura Y, Nomura T, Sakai K, Sasaki K, Ohguchi Y, Mizuno O, Hata H, Aoyagi S, Abe R, Itaya Y, Akiyama M, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: 168 Pages: 206-209

    • DOI

      10.1111/j.1365-2133.2012.11174.x

    • Peer Reviewed
  • [Journal Article] Wells' Syndrome Associated with Chronic Myeloid Leukaemia2013

    • Author(s)
      Nakazato S, Fujita Y, Hamade Y, Nemoto-Hasebe I, Sugita J, Nishie W, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 375-376

    • DOI

      10.2340/00015555-1483

    • Peer Reviewed
  • [Journal Article] c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis2013

    • Author(s)
      Cottle DL, Kretzschmar K, Schweiger PJ, Quist SR, Gollnick HP, Natsuga K, Aoyagi S, Watt FM
    • Journal Title

      Cell Rep

      Volume: 3 Pages: 427-441

    • DOI

      10.1016/j.celrep.2013.01.013

    • Peer Reviewed
  • [Journal Article] A method for intravital monitoring of human cells using a far-red luminescent probe in graft-versus-host disease model mice2013

    • Author(s)
      Qiao H, Abe R, Saito N, Fujita Y, Hayashi-Ujiie I, Wang G, Haga S, Wu C, Ohmiya Y, Ozaki M, Shimizu H
    • Journal Title

      J Invest Dermatol

      Volume: 133 Pages: 841-84

    • DOI

      10.1038/jid.2012.345

    • Peer Reviewed
  • [Journal Article] Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients2013

    • Author(s)
      Saito N, Yoshioka N, Abe R, Qiao H, Fujita Y, Hoshina D, Suto A, Kase S, Kitaichi N, Ozaki M, Shimizu H
    • Journal Title

      J Allergy Clin Immunol

      Volume: 131 Pages: 434-441, e431-439

    • DOI

      10.1016/j.jaci.2012.09.014

    • Peer Reviewed
  • [Journal Article] Cutaneous Manifestations of Helicobacter cinaedi Infection2013

    • Author(s)
      Shimizu S, Inokuma D, Watanabe M, Sakai T, Yamamoto S, Tsuchiya K, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 165-167

    • DOI

      10.2340/00015555-1396

    • Peer Reviewed
  • [Journal Article] A Novel Keratin 5 Mutation in an African Family with Epidermolysis Bullosa Simplex Indicates the Importance of the Amino Acid Located at the Boundary Site Between the H1 and Coil 1A Domains2013

    • Author(s)
      Shinkuma S, Nishie W, Jacyk WK, Natsuga K, Ujiie H, Nakamura H, Akiyama M, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Pages: 585-587

    • DOI

      10.2340/00015555-1538

    • Peer Reviewed
  • [Journal Article] Prevalent founder mutation c.736T>A of LIPH in autosomal recessive woolly hair of Japanese leads to variable severity of hypotrichosis in adulthood2013

    • Author(s)
      Tanahashi K, Sugiura K, Takeichi T, Takama H, Shinkuma S, Shimizu H, Akiyama M
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 27 Pages: 1182-1184

    • DOI

      10.1111/j.1468-3083.2012.04526.x

    • Peer Reviewed
  • [Journal Article] LC-MS/MS analysis of canine lipoproteins fractionated using the ultracentrifugation-precipitation method2013

    • Author(s)
      Suto A, Yamasaki M, Takasaki Y, Fujita Y, Abe R, Shimizu H, Ohta H, Takiguchi M
    • Journal Title

      J Vet Med Sci

      Volume: 75 Pages: 1471-1477

    • Peer Reviewed
  • [Journal Article] Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain Fatty Acid production2013

    • Author(s)
      Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A
    • Journal Title

      Mol Cell Biol

      Volume: 33 Pages: 2787-2796

    • DOI

      10.1128/MCB.00192-13

    • Peer Reviewed
  • [Journal Article] Indomethacin for Refractory Infantile Eosinophilic Pustular Folliculitis2013

    • Author(s)
      Toyonaga E, Abe R, Moriuchi R, Ito K, Abe Y, Shimizu H
    • Journal Title

      JAMA Dermatol

      Volume: 149 Pages: 367-368

    • DOI

      10.1001/2013.jamadermatol.591

    • Peer Reviewed
  • [Journal Article] Pagetoid dyskeratosis with parallel ridge pattern under dermoscopy2013

    • Author(s)
      Toyonaga E, Inokuma D, Abe Y, Abe R, Shimizu H
    • Journal Title

      JAMA Dermatol

      Volume: 149 Pages: 109-111

    • DOI

      10.1001/archdermatol.2012.3201

    • Peer Reviewed
  • [Journal Article] Disturbed balance in three subpopulations of CD4(+)Foxp3(+) regulatory T cells in Stevens-Johnson syndrome and toxic epidermal necrolysis patients2013

    • Author(s)
      Yoshioka N, Suto A, Abe R, Saito N, Murata J, Hayashi-Ujiie I, Hoshina D, Fujita Y, Shimizu H
    • Journal Title

      Clin Immunol

      Volume: 148 Pages: 89-91

    • DOI

      10.1016/j.clim.2013.04.002

    • Peer Reviewed
  • [Journal Article] Recurrent course and CD30 expression of atypical T lymphocytes distinguish lymphomatoid papulosis type D from primary cutaneous aggressive epidermotropic CD8 + cytotoxic T-cell lymphoma

    • Author(s)
      Tsujiwaki M, Abe R, Ohguchi Y, Hoshina D, Murata J, Fujita Y, Nomura T, Ambo M, Shimizu H
    • Journal Title

      Acta Dermato Venereol

      Volume: (in press)

    • DOI

      10.2340/00015555-1806

    • Peer Reviewed
  • [Journal Article] Nanoparticle albumin-bound paclitaxel can be useful agent to advanced primary mucinous carcinoma of the skin

    • Author(s)
      Ohguchi Y, Nomura T, Suzuki S, Mizuno O, Nomura Y, Nomoto-Hasebe I, Okamoto H, Sandilands A, Akiyama M, McLean WH, Shimizu H
    • Journal Title

      Dermatologic therapy

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Punctate palmoplantar keratoderma type 1 : a novel AAGAB mutation and efficacy of etretinate

    • Author(s)
      Nomura T, Yoneta A, Pohler E, Suzuki S, Osawa R, Mizuno O, Ohguchi Y, Nomura Y, Yamashita T, McLean W, Shimizu H
    • Journal Title

      Acta Dermato Venereol

      Volume: (in press)

    • DOI

      10.2340/00015555-1832

    • Peer Reviewed
  • [Journal Article] Highly prevalent SERPINB7 founder mutation causes pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis

    • Author(s)
      Mizuno O, Nomura T, Suzuki S, Takeda M, Ohguchi Y, Fujita Y, Nishie W, Sugiura K, Akiyama M, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: (in press)

    • DOI

      10.1111/bjd.13076

    • Peer Reviewed
  • [Journal Article] Loss-of-function mutations in the gene encoding filaggrin underlie a Japanese family with food-dependent exercise-induced anaphylaxis

    • Author(s)
      Mizuno O, Nomura T, Ohguchi Y, Suzuki S, Nomura Y, Hamade Y, Hoshina D, Sandilands A, Akiyama M, McLean WH, Abe R, Shimizu H
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: (in press)

    • DOI

      10.1111/jdv.12441

    • Peer Reviewed
  • [Journal Article] Comprehensive screening for a complete set of Japanese-population-specific filaggrin gene mutations

    • Author(s)
      Kono M, Nomura T, Ohguchi Y, Mizuno O, Suzuki S, Tsujiuchi H, Hamajima M, McLean W, Shimizu H, Akiyama M
    • Journal Title

      Allergy

      Volume: (in press)

    • DOI

      10.1111/all.12369

    • Peer Reviewed
  • [Journal Article] Tubular apocrine adenoma clinically and dermoscopically mimicking basal cell carcinoma

    • Author(s)
      Ito T, Nomura T, Fujita Y, Abe R, Shimizu H
    • Journal Title

      J Am Acad Dermatol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Paper-Based ELISA for the Detection of Autoimmune Antibodies in Body Fluid-The Case of Bullous Pemphigoid

    • Author(s)
      Hsu CK, Huang HY, Chen WR, Nishie W, Ujiie H, Natsuga K, Fan ST, Wang HK, Lee JY, Tsai WL, Shimizu H, Cheng CM
    • Journal Title

      Anal Chem

      Volume: (in press)

    • DOI

      10.1021/ac500835k

    • Peer Reviewed
  • [Journal Article] Solitary tumor on the neck

    • Author(s)
      Horie K, Abe R, Murata J, Nomura T, Shimizu H
    • Journal Title

      Acta Dermato Venereol

      Volume: (in press)

    • DOI

      10.2340/00015555-1792

    • Peer Reviewed
  • [Journal Article] Primary mucinous carcinoma of the skin with in-transit metastasis

    • Author(s)
      Homma E, Hata H, Aoyagi S, Shimizu H
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: (in press)

    • DOI

      10.1111/jdv.12533

    • Peer Reviewed
  • [Journal Article] Nanoparticle albumin-bound paclitaxel can be useful agent to advanced primary mucinous carcinoma of the skin.

    • Author(s)
      Homma E, Hata H, Aoyagi S, Shimizu H
    • Journal Title

      Dermatologic therapy

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Ultrasound B-mode and Elastographic Findings of Angiomatoid Fibrous Histiocytoma.

    • Author(s)
      Hata H, Natsuga K, Homma E, Aoyagi S, Shimizu H
    • Journal Title

      Clin Exp Dermatol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] MUC5AC expression correlates with invasiveness and progression of extramammary Paget's disease

    • Author(s)
      Hata H, Abe R, Hoshina D, Saito N, Homma E, Aoyagi S, Shimizu H
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: (in press)

    • DOI

      10.1111/ced.12314

    • Peer Reviewed
  • [Journal Article] Two cases of pseudolymphoma on the lips

    • Author(s)
      Haga N, Nishie W, Hata H, Miyauchi T, Muramatsu K, Kitamura S, Osawa R, Shimizu H
    • Journal Title

      Br J Dermatol

      Volume: (in press)

    • DOI

      10.1111/bjd.12837

    • Peer Reviewed
  • [Journal Article] Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility

    • Author(s)
      Cipolat S, Hoste E, Natsuga K, Quist S, Watt FM
    • Journal Title

      eLife

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Dermoscopic Features of Plasma Cell Cheilitis and Actinic Cheilitis

    • Author(s)
      Ito T, Natsuga K, Tanimura S, Aoyagi S, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: (in press)

    • DOI

      10.2340/00015555-1795

    • Peer Reviewed
  • [Presentation] Pathogenetic mechanisms in autoimmune skin fragility.2013

    • Author(s)
      Natsuga K
    • Organizer
      The 40th Annual Meeting of Society for Cutaneous Ultrastructure Research
    • Place of Presentation
      Salzburg, Austria
    • Year and Date
      20130512-14
    • Invited
  • [Presentation] Skin barrier defect allows more abundant microbiota in skin and induces skin inflammation and the expression of antimicrobial peptides independently of microbiota : Skin barrier defect allows more abundant microbiota in skin and induces skin inflammation and the expression of antimicrobial peptides independently of microbiota.2013

    • Author(s)
      Natsuga K, Cipolat S, Watt FM
    • Organizer
      The International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Year and Date
      20130508-11
  • [Presentation] Detection of pathological cleavage sites and neoepitopes on collagen XVII, a major autoantigen for bullous pemphigoid.2013

    • Author(s)
      Nishie W, Ujiie H, Izumi K, Shimizu H
    • Organizer
      The International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, Scotland
    • Year and Date
      20130508-11
  • [Presentation] Shedding of the type VII collagen. The International Pre IID2013

    • Author(s)
      Nishie W
    • Organizer
      2013 Meeting on Autoimmune Bullous Diseases
    • Place of Presentation
      .Luebeck, Germany
    • Year and Date
      20130506-07
    • Invited
  • [Book] Epidermolysis bullosa simplex Current Genetics in Dermatology2013

    • Author(s)
      Natsuga K
    • Total Pages
      31-46
    • Publisher
      Intech
  • [Book] Mouse models of autoimmune blistering diseases induced by the passive transfer of antibodies. Methods Mol Biol 9612013

    • Author(s)
      Nishie W
    • Total Pages
      363-369
  • [Remarks]

    • URL

      http://www.derm-hokudai.jp/jp/

URL: 

Published: 2015-06-25   Modified: 2015-08-12  

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