2016 Fiscal Year Final Research Report
Grouping by brain network for tailor-made intervention of autism spectrum disorders
| Project/Area Number |
25670511
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 自閉スペクトラム症 / 疫学研究 / 分子遺伝研究 / 脳イメージング / 拡散テンソル画像 |
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| Outline of Final Research Achievements |
Rates of children with doubt of Autism spectrum disorder (ASD), in medical examination at the time of entering school, were 2.0% (45/2937) in Niigata city. As a risk factor of ASD, we identified a family history of mental disorders. In our imaging study using diffusion tensor imaging, we found a significant Fractional anisotropy (FA) decrease in thalamus-fornix region and increase in left middle cerebellar peduncle in the ASD group. “Switching of attention” score, which is a subscale score of Autism-spectrum Quotient (AQ), was correlated negatively with FA. In our molecular genetic study, to investigate the role of rare variations, we performed whole-exome sequencing (WES) with affected siblings. Ｗe identified rare risk candidate genes for ASD (2015 PLoS One; 2015 Psychiatry Res) .
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| Free Research Field |
精神医学
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