The identification of biomarker for the circadian rhythm of clock gene of the bipolar disorder

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670518
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: Haga Toshiaki 聖マリアンナ医科大学, 医学部, 研究技術員 (80535625)
• Co-Investigator(Kenkyū-buntansha): 長田 賢一 聖マリアンナ医科大学, 医学部, 准教授 (20233504) ; 貴家 康男 聖マリアンナ医科大学, 医学部, 講師 (60308450) ; 中野 三穂 聖マリアンナ医科大学, 医学部, 助教 (90621574)
• Co-Investigator(Renkei-kenkyūsha): MATSUI Hiroaki 聖マリアンナ医科大学, 医学部, 教授 (90181685)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 時計遺伝子

Outline of Final Research Achievements

Mental disorder caused by abnormality of the circadian rhythm of sleep-wake cycles has a many report. Above all, clock gene is important. We measured the mRNA expression of the clock gene from the hypothalamus and hippocampus which are central nervous system, and the submandibular gland which was a peripheral tissue. The clock gene developed in hypothalamus, hippocampus and submandibular glands and was found to form circadian rhythm in a period for 24 hours. Furthermore, the amplitude of the rhythm was more widely found in a peripheral tissue than central nervous system.

Free Research Field

神経科学