Cerenkov luminescence imaging using PET probes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670528
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University (2015); Hamamatsu University School of Medicine (2013-2014)
• Principal Investigator: OGAWA Mikako 北海道大学, 薬学研究科(研究院), 教授 (20344351)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: チェレンコフ光 / PETプローブ

Outline of Final Research Achievements

Optical imaging has advantages in its easy-to-use feature. But, in general, optical imaging probes have large molecular weight and it is difficult to do brain imaging. On the other hands, PET imaging is superior in quantitative analysis, and many brain imaging probes are available. It is now of great interest performing cerenkov luminescence imaging (CLI) by PET probes. In this study, we evaluated the feasibility of CLI for the analysis of brain function.
In [18F]FDG studies, there was a good relationship between the radioactivity and CLI signal in brains. [11C]raclopride and [11C]b-CFT imaging was also successful, and luminescence in the striatum was decreased by haloperidol (D2 receptor ligand) treatment until 30 min post injection of [11C]raclopride. [11C]b-CFT produced more clearer images than [11C]raclopride. Although the quantitativity is inferior to PET imaging, it is revealed that CRI can be applied for brain function analysis in mice.

Free Research Field

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