Development of radiolabeled probes for molecular imaging of AA amyloidosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670540
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: MUKAI Takahiro 神戸薬科大学, 薬学部, 教授 (30284706)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Masafumi 神戸薬科大学, 薬学部, 講師 (40411904) ; HAGIMORI Masayori 神戸薬科大学, 薬学部, 講師 (40446125)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 薬学 / 放射線 / イメージング

Outline of Final Research Achievements

For nuclear imaging of AA amyloidosis, we synthesized and evaluated a radioiodinated Thioflavin T derivative 13. In mouse plasma, [I-125]13 showed high stability after 24-h incubation. In normal mice, [I-125]13 showed rapid blood clearance and high accumulation of radioactivity in kidney, liver and spleen at early time points. Little accumulation of radioactivity in brain suggested that [I-125]13 would not across the blood-brain barrier. The accumulation of radioactivity in thyroid was also very low indicating high in vivo stability against deiodination reaction. After 24 h, about 70% of radioactivity was excreted from the body.

Free Research Field

放射線科学