2014 Fiscal Year Final Research Report
Development of radiolabeled probes for molecular imaging of AA amyloidosis
Project/Area Number |
25670540
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Kobe Pharmaceutical University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
TANAKA Masafumi 神戸薬科大学, 薬学部, 講師 (40411904)
HAGIMORI Masayori 神戸薬科大学, 薬学部, 講師 (40446125)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | 薬学 / 放射線 / イメージング |
Outline of Final Research Achievements |
For nuclear imaging of AA amyloidosis, we synthesized and evaluated a radioiodinated Thioflavin T derivative 13. In mouse plasma, [I-125]13 showed high stability after 24-h incubation. In normal mice, [I-125]13 showed rapid blood clearance and high accumulation of radioactivity in kidney, liver and spleen at early time points. Little accumulation of radioactivity in brain suggested that [I-125]13 would not across the blood-brain barrier. The accumulation of radioactivity in thyroid was also very low indicating high in vivo stability against deiodination reaction. After 24 h, about 70% of radioactivity was excreted from the body.
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Free Research Field |
放射線科学
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