Analysis of irradiation effects on post-transcriptional control of gene expression by a newly developed method

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670542
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kurume University
• Principal Investigator: OKU Eijiro 久留米大学, 医学部, 講師 (10569429)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 遺伝子発現調節 / 放射線生物学

Outline of Final Research Achievements

Recently, post-transcriptional control of gene expression, mediated by such as microRNA and/or RNA-binding protein, has been considered to play an important role in gene regulation. In this study, we developed a novel method to discover a set of genes of post-transcriptionally regulation using retrovirus vector system. In order to find out genes with post-transcriptionally regulation affected by radiation, we applied this method to pleuripotent stem cell as well as hematopoietic stem cell with or without irradiation and could detect sets of genes of interest. We will perform further investigation to find out genes for therapeutic targets and to clarify the underlying mechanism of translational control.

Free Research Field

腫瘍内科