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2014 Fiscal Year Final Research Report

Novel radionuclide-ligand complexes encapsulated in liposomes for tumor-selective radionuclide therapy

Research Project

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Project/Area Number 25670546
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

UMEDA Izumi, O.  独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (40160791)

Co-Investigator(Renkei-kenkyūsha) KIMURA Sadaaki  独立行政法人国立がん研究センター, 臨床開発センター, 研究員 (10585029)
Project Period (FY) 2013-04-01 – 2015-03-31
Keywords内用療法 / リポソーム / 放射性核種 / 錯体化学 / がん / In-111 / Y-90
Outline of Final Research Achievements

Application of radionuclide-carrying liposomes to radionuclide therapy for cancer is promising as liposomes are able to deliver large amount of radionuclides to the tumor. However, radionuclides also accumulate in normal tissues such as the liver non-specifically, and cause abdominal radiation exposure. In this study, we devised a strategy whereby radionuclides with the property of metal ions and various chelating ligands to them were encapsulated in liposomes to promote the radionuclide clearance from the normal tissues.

Free Research Field

放射性医薬品化学

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Published: 2016-06-03  

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