Thermosensitive particles which release anticancer agent by applying magnetic field

2013 Fiscal Year Final Research Report

• Project/Area Number: 25670550
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Akita University
• Principal Investigator: SAITO Hajime 秋田大学, 医学(系)研究科(研究院), 准教授 (20323149)
• Project Period (FY): 2013-04-01 – 2014-03-31
• Keywords: 磁性体 / がん / 温熱療法

Research Abstract

We have developed a method of magnetically induced hyperthermia using thermosensitive ferromagnetic particles (FMPs) with low Curie temperature (Tc) enough to mediate automatic temperature control. In this work, we evaluated the effect of our original hyperthermia system combined with the delivery of anticancer drug from nanogel particles in vitro. A nanogel based on polymerised N-isopropylacrylamide (NIPAM) was synthesized, characterized and loaded with methotrexate (MTX). The result was that diameter of thermosensitive particles reduced dependent on increasing temperature, and MTX was released significantly. The proliferation of cultured cancer cells was inhibited by MTX combined with our original hyperthermia system.
Further investigation, including in vivo experiment, was needed to making them ideal candidates for cancer thermo-chemotherapy.