The heterogeneity of tumor endothelial cells of hepatocellular carcinoma and the application to novel molecular targeted therapies

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670564
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Hokkaido University
• Principal Investigator: TAKAHASHI Norihiko 北海道大学, 大学病院, 准教授 (30399894)
• Co-Investigator(Kenkyū-buntansha): HONMA Shigenori 北海道大学, 北海道大学病院, 助教 (30533674) ; SHIMOKUNI Tatsushi 北海道大学, 北海道大学病院, 特任教授 (30596458) ; OHGA Noritaka 北海道大学, 大学院歯学研究科, 助教 (40548202) ; SAKIHAMA Hideyasu 北海道大学, 北海道大学病院, 特任助教 (50533676) ; TAKETOMI Akinobu 北海道大学, 大学院医学研究科, 教授 (70363364)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腫瘍血管新生

Outline of Final Research Achievements

We have reported that tumor endothelial cells are heterogeneous depending on tumor malignancy. In this study, we tried to evaluate the difference of tumor endothelial cells of hepatocellular carcinoma, in order to develop novel molecular for targeting liver cancer. We identified a marker that is highly expressed in poorly differentiated cancer compared to well-differentiated cancer and show that this molecule plays an important role for tumor cell metastasis. These results suggested that tumor endothelial cell may be involved in tumor metastasis in malignant hepatocellular carcinoma.

Free Research Field

消化器外科学