Development of a novel treatment for micro metastatic tumors derived from cholangiocarcinoma using mesenchymal stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670566
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: KATAYOSE YU 東北大学, 医学(系)研究科(研究院), 大学院非常勤講師 (20302151)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Kei 東北大学, 医学(系)研究科(研究院), 講師 (20542294) ; RIKIYAMA Toshiki 自治医科大学, 医学部, 教授 (80343060)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 間葉系幹細胞 / 多能性幹細胞 / 胆管癌

Outline of Final Research Achievements

In spite of the progress of treatment for cholangiocarcinoma, the prognosis is still not good. One of the reasons for the poor prognosis is a difficulty in prevention of micro metastases, which are hardly to identify by any imaging examinations. We estimated that it is necessary for improvement of the prognosis to eliminate the micro metastases, and therefore, aimed to develop a novel treatment using multiliniage-differentiating stress enduring (Muse) cells, which are the components of mesenchymal stem cells.

Free Research Field

医歯薬学