2015 Fiscal Year Final Research Report
Analysis of the mechanism for liver metastasis and theresistance to anticancer agents of colorectal cancer
| Project/Area Number |
25670573
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Gifu University |
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Principal Investigator |
OKUMURA NAOKI 岐阜大学, 医学(系)研究科(研究院), 助教 (80422715)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | c-Met / HGF / colorectal cancer / liver metastasis / TGF-β |
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| Outline of Final Research Achievements |
There is a difference in the signaling pathway that HGF and TGF express EMT,even though HGF also induce EMT in the same manner as TGF. That is HGF induces EMT through the ERK / Akt pathway. HGF enhance the effect of 5FU by attenuating the thymidine synthase through the cyclin D1 / E2F-related pathway.
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| Free Research Field |
医歯薬学
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