2015 Fiscal Year Final Research Report
Functional analysis of novel genes based on molecular evolution
| Project/Area Number |
25670574
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGINO MASATO 名古屋大学, 医学系研究科, 教授 (20237564)
KOKURYO TOSHIO 名古屋大学, 医学系研究科, 特任講師 (60378023)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 分子進化 |
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| Outline of Final Research Achievements |
Various amino acids, such as tyrosine, leucine, methionine, tryptophan, asparagine, aspartic acid, alanine, arginine, isoleucine, glycine, glutamine, cysteine, serine, histidine, proline, lysine, valine, threonine and phenylalanine, induce altered expression of endothelin 1 in RAW cells after LPS administration. Cysteine (40 mM) suppressed endothelin 1 expression and the induction of iNOS in RAW cells. Administration of several amino acids induced significant alterations in intracellular calcium concentrations. These results suggest that amino acids are related to calcium concentrations both inside and outside the cell.
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| Free Research Field |
外科学
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