The role of macrophage of spleen in wound healing and cancer progression

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670583
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: Shirabe Ken 九州大学, 医学(系)研究科(研究院), 共同研究員 (70264025)
• Co-Investigator(Kenkyū-buntansha): SOEJIMA Yuji 九州大学, 医学研究院, 共同研究員 (30325526) ; IKEDA Tetsuo 九州大学, 大学病院, 准教授 (60585701) ; YOSHIZUMI Tmoharu 九州大学, 医学研究院, 准教授 (80363373) ; IKEGAMI Toru 九州大学, 大学病院, 助教 (80432938)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脾臓 / 創傷治癒 / 肝癌 / 免疫

Outline of Final Research Achievements

In terms of wound healing study, skin defect mice model was established. And Ly6C macrophage, which was reported to be related to wound healing, was harvested from spleen. Although splenectomy in skin defect mice modelwas performed, there was no significant difference in wound healing between mice with and without splenectomy.
In terms of cancer progression, our clinical data showed that splenomegaly was significant poor prognostic factor after hepatectomy for hepatocellular carcinoma（HCC). The prognosis after hepatectomy for HCC and simultaneous splenectomy for splenomegaly was same as that in those who underwent hepatectomy for HCC and without splenomegaly. Splenectomy may improve long term prognosis after hepatectomy. We showed that the number of immunosuppressive cells increased in the spleen in the patients with liver cirrhosis (LC). Therefore, in the patients with LC, the cause of immunosuppressive state may be spleen.

Free Research Field

肝臓外科学