The development of the therapy for metastatic pancreatic cancer targeting its microenvironment.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670591
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: YAMANAMI Hideaki 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 共同研究員 (70270840)
• Co-Investigator(Kenkyū-buntansha): SATOH Kennichi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (10282055)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 膵癌 / 微小環境 / ペリオスチン

Outline of Final Research Achievements

Cancer stroma (microenvironment) is shown to be involved in pancreatic cancer development. Periostin, which is expressed in stroma, is suggested to be an important molecule related to pancreatic cancer progression. To assess the possibility of development of the effective therapy for pancreatic cancer by targeting Periosin, we compared the pancreatic tissues derived from Pdx1-cre; K-ras G12D; Periostin+/+ with Pdx1-cre; K-ras G12D; Periostin-/- mice. PanIN formation was delayed in Periostin-/- compared to Periostin+/+ mice, suggesting that Periostin is involved in pancreatic carcinogenesis and might be therapeutic target.

Free Research Field

消化器外科学