2014 Fiscal Year Final Research Report
CSDA, as a novel suppressor of intimal hyperplasia.
| Project/Area Number |
25670592
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 内膜肥厚 / 遺伝子治療 |
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| Outline of Final Research Achievements |
Background: Intimal hyperplasia (IH) is the main cause of clinical complication after vascular surgery or angioplasty. Objective: The goal of the present study is to investigate the therapeutic efficacy of CSDA on IH. Methods and Results: Gene transfer of CSDA suppressed cellar proliferation (MTS assay) and migration (modified Boyden chamber method) of VSMCs, via down-regulation of E2F，NFkB，SRE，CRE，and HIF activity. We established the wire-injury mouse model. Now we plan the CSDA gene therapy on this model. Conclusion: We believed that CSDA is a novel multi-functional therapeutic molecule for IH.
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| Free Research Field |
血管外科
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