Development of the novel valved stent composed of completely autologous tissue from Japan.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670601
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: MIZUNO Takeshi 独立行政法人国立循環器病研究センター, 研究所, 特任研究員 (50632741)
• Co-Investigator(Kenkyū-buntansha): YAMANAMI Masashi 国立循環器病研究センター, 研究所, 非常勤研究員 (30438204) ; NAKAYAMA Yasuhide 国立循環器病研究センター, 研究所, 室長 (50250262) ; IWAI Ryosuke 国立循環器病研究センター, 研究所, 流動研究員 (60611481)
• Co-Investigator(Renkei-kenkyūsha): MORIWAKI Takeshi 国立循環器病研究センター, 研究所, 非常勤研究員 (50707213)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 組織工学弁 / 経カテーテル的弁置換術 / 心臓血管外科

Outline of Final Research Achievements

The aim of this study was to develop the stent-biovalve composed of autologous connective tissue by using 'in-body architecture technology' for transcatheter mitral valve replacement.
(1) We developed a novel technique that was highly effective in constructing a robust, completely autologous stent-biovalve with adequate valve function.
(2) By using this new method, we succeeded fabricating linked stent-biovalves suitable for atrioventricular valves. We succeeded transcatheter mitral valve replacement with stent-biovalve and the stent-biovalve showed good valve function at the mitral position in the short study period in an beagle dog.

Free Research Field

心臓血管外科