Generation of artificial lung cancer stem cells and its regulation by microenvironment in order to develop the effective therapeutic strategy for lung cancer.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670611
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: ABE Jiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 特任研究員 (10573686)
• Co-Investigator(Kenkyū-buntansha): SATOH Kennichi (10282055)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 肺癌 / 人工がん幹細胞 / HOTAIR

Outline of Final Research Achievements

In order to develop the new therapeutic strategy for non-small cell lung cancer (NSCLC)　stem cell, we tried to establish artificial cancer stem cell line. As cancer stem cell related molecule, we focused on large non-coding RNA HOTAIR. Lung cancer cells (A549) showed increased cellular migration in HOTAIR dependent munner. In addition, the expression of HOTAIR was found especially in aggressive NSCLC and was significantly correlated with shorter disease free survival, suggesting that HOTAIR might be involved in the property of cancer stem cell of NSCLC.

Free Research Field

呼吸器外科学