Roles for pyruvate kinase M in metabolic rewiring during gliomagenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670627
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: KATAKURA RYUICHI 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (10442675)
• Co-Investigator(Kenkyū-buntansha): TANUMA Nobuhiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645) ; ITO Shigemi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 代謝 / 解糖系 / ワールブルグ効果 / PKM / グリオーマ

Outline of Final Research Achievements

Two isoforms of pyruvate kinase M (Pkm), Pkm1 and Pkm2, differentially control flux of carbon sources from glycolysis to TCA cycle. We developed novel mice in which splicing regulation of Pkm1/2 is disabled. Also, we identified about 20 compounds that inhibit Pkm activity of cells. Further analysis showed that these compounds indirectly regulate pyruvate kinase through modulation of signal transduction and/or cellular metabolism.

Free Research Field

脳神経外科学