Light-induced regulation of the function of osteocyte and bone remodelling

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670638
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Osaka Dental University (2014); Tokyo Medical and Dental University (2013)
• Principal Investigator: NOTOMI Takuya 大阪歯科大学, 歯学部, 講師 (70542249)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 骨代謝

Outline of Final Research Achievements

Age-related bone diseases such as osteoporosis are serious problem in an aged society and their treatment is necessary for maintaining QOL. To prevent bone diseases, we have done the study of role of membrane potential and ion channels on bone cells. To challenge the regulation of osteocyte function in vitro culture, we overexpressed light-sensitive ion channel and pump. The light-sensitive ion channels and pump were transfected into osteocyte and then we investigated the role of membrane potential on those cells. In electrophysiological experiments, the membrane potential was controlled by light stimulus. The light stimulus regulated some portion of osteocyte function. In summary, our results indicate that membrane potential regulate some of osteocyte functions. Our system could regulate the membrane potential and function in osteocyte.

Free Research Field

骨生物学