Identification of proteins for multi-drug resistance in bone and soft tissue sarcoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670650
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Okayama University
• Principal Investigator: Ozaki Toshifumi 岡山大学, 医歯(薬)学総合研究科, 教授 (40294459)
• Co-Investigator(Kenkyū-buntansha): SUGIHARA SHINSUKE 独立行政法人国立病院機構, 四国がんセンター(臨床研究センター), 研究員 (60314671) ; TAKEDA KEN 岡山大学, 医歯(薬)学総合研究科, 助教 (70614923)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨肉腫 / 薬剤耐性 / 質量分析

Outline of Final Research Achievements

Chemoresistance is a poor prognostic factor in osteosaroma and is a major obstacle to the successful treatment of patients receiving chemotherapy. However, the precise mechanism of resistance remains unclear. In this study, a pair of osteosarcoma cell lines, MNNG/HOS, U2OS and its adriamycin-resistant counterpart MNNG/HOS-ADR and U2OS/ADR were used to examine resistance-dependent cellular responses and to identify potential chemotherapeutic resistant targets. About three thousand proteins were identified in this study.

Free Research Field

骨軟部腫瘍