2014 Fiscal Year Final Research Report
Analysis of the role of pH-sensing receptors in arthritis using receptor-deficient mice
| Project/Area Number |
25670657
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | コラーゲン関節リウマチモデル / Imidazopyridine化合物 / GPR4 |
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| Outline of Final Research Achievements |
It is suggested that acidic microenvironment takes place in inflammatory sites in rheumatoid arthritis due to the stimulation of anaerobic glycolysis by infiltrated inflammatory cells. However, how acidification is involved in the pathophysiology remains unknown. In the current study, we planed to know the role of proton-sensing GPCRs, especially GPR4, in the development of arthritis. To this end, we analyzed the collagen-induced arthritis model using GPR4 knockout mouse. We also characterized chemicals which affect GPR4 activities in order to develop novel drugs related to GPR4.
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| Free Research Field |
解剖生理学
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