2014 Fiscal Year Final Research Report
Elucidation of mechanism of tourniquet pain
| Project/Area Number |
25670668
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Niigata University |
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Principal Investigator |
KOHNO Tatsuro 新潟大学, 医歯学系, 准教授 (00313536)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBUKI Katsuei 新潟大学, 脳研究所, 教授 (40146163)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | タニケットペイン / しびれ / フラビン蛍光蛋白 |
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| Outline of Final Research Achievements |
Transient ischemia produces postischemic tingling sensation. Ischemia also produces nerve conduction block that may modulate spinal neural circuits. Neural activities were investigated using activity-dependent changes in endogenous fluorescence derived from mitochondrial flavoproteins. Ischemic treatment induced potentiation of the ipsilateral spinal responses to hindpaw stimulation. The present findings suggest that neural plasticity in the spinal cord shares the mechanisms, at least in part, with postischemic tingling sensation.
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| Free Research Field |
麻酔科学
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