Establishment of the new concept, 'spontaneous elimination of kidney stones' and application to development of the dissolution therapy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670685
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: OKADA ATSUSHI 名古屋市立大学, 医学(系)研究科(研究院), 講師 (70444966)
• Co-Investigator(Kenkyū-buntansha): KOHRI Kenjiro 名古屋市立大学, 学長 (30122047) ; YASUI Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153) ; HIROSE Masahito 名古屋市立大学, 大学院医学研究科, 研究員 (70529172) ; HAMAMOTO Shuzo 名古屋市立大学, 大学院医学研究科, 助教 (80551267) ; Niimi Kazuhiro 名古屋市立大学, 大学院医学研究科, 研究員 (70551274) ; Hirose Yasuhiko 名古屋市立大学, 大学院医学研究科, 研究員 (60381894)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 尿路結石 / マクロファージ / op/op / Randall's plaque / M2マクロファージ

Outline of Final Research Achievements

We discovered the new phenomenon, "spontaneous elimination of kidney stones " ahead of the world. Furthermore, We proved that the crystal phagocytosis by the anti-inflammatory macrophages (M2-typed Mφs) affected this phenomenon. Based on these results, this study analyzed M2-typed Mφs deficient mice and the genome-wide expression using the human renal papilla tissue for development of the dissolution therapy of the kidney stones.
There was significantly increased number of stones in the M2-typed Mφ deficient mice, and decreased expression of genes related with immunity, inflammation was recognized in comparison with the wild-type mice in the stone formative period. In addition, We recognized decreased expression of the M2-typed Mφ-related gene clusters in the Randall's plaques which is the original part of kidney stones at the human renal papilla tissues.

Free Research Field

尿路結石