Binding of sperm and oocyte induced by gut factor: Novel strategy for treatment of male infertility

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670692
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Akita University
• Principal Investigator: YAMADA Yuichiro 秋田大学, 医学(系)研究科(研究院), 教授 (60283610)
• Co-Investigator(Kenkyū-buntansha): TERADA Yukihiro 秋田大学, 大学院医学系研究科, 教授 (10260431)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: インクレチン / 不妊

Outline of Final Research Achievements

GIP, which is secreted from endocrine K cells of small intestine, not only stimulates insulin secretion from pancreatic beta-cells but also exerts various extra-pancreatic effects. We have shown that GIP receptors are highly expressed in testis, knockout of GIP receptor leads to decreased artificial fertilization, and expression of factor X is decreased in testis of GIP receptor KO mice and high fat-fed mice, that factor X may be involved in binding of sperm and oocytes. These results suggests that GIP signaling and factor X are participated in male infertility induced by high fat or over-eating.

Free Research Field

臨床医学、内科学、糖尿病学、内分泌学