Elucidation of novel factors contributing to the aquisition of uterine receptivity

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670695
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: HIROTA YASUSHI 東京大学, 医学部附属病院, 講師 (40598653)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 着床 / 胚受容能 / 子宮 / プロゲステロン / プロゲステロン受容体 / 妊娠

Outline of Final Research Achievements

The embryo does not normally implant in the cervix but in the uterus. Stromal proliferation and epithelial differentiation, what we here call the proliferation/differentiation switching (PDS), occurs in the receptive uterus. We found that progesterone (P) signaling induces PDS and successful implantation in the receptive uterus, while elevated microRNA-200a leads to the reduction of PR expression and the promotion of P metabolism, and further non-responsiveness of PDS in the cervix. These findings indicate that P signaling deficiency by microRNA-200a confers cervical non-responsiveness to embryo implantation.

Free Research Field

産婦人科学、生殖医学、生殖生物学