Role of estrogen via the recruitment of Treg in the control of glucose homeostasis in female mice.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670697
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: University of Toyama
• Principal Investigator: TOSHIYASU Sasaoka 富山大学, 大学院医学薬学研究部(薬学), 教授 (00272906)
• Co-Investigator(Kenkyū-buntansha): TSUNEKI Hiroshi 富山大学, 大学院医学薬学研究部(薬学), 准教授 (20332661) ; WADA Tsutomu 富山大学, 大学院医学薬学研究部(薬学), 講師 (00419334)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: エストロゲン / インスリン抵抗性 / 糖代謝 / 免疫 / T細胞

Outline of Final Research Achievements

Estrogen is involved in the glucose homeostasis in addition to the regulation of estrous cycle and gestation. In the present study, we examined whether estrogen regulates glucose metabolism by inhibition of chronic inflammation via regulatory T cells (Treg)-mediated alteration of macrophage function. Treg in the vascular adipose disuse was decreased in male mice on high-fat diet (HFD). In contrast, Treg was increased on HFD, and was decreased by ovariectomy in female mice. In addition, the chronic inflammation by HFD was suppressed in female mice, whereas it was apparent in male mice and in female ovariectomized mice on HFD. These results indicate that estrogen protects against obesity-mediated metabolic abnormalities by affecting Treg in the vascular adipose tissue in female mice.

Free Research Field

糖尿病・内分泌学