Prediction and prevention of abruptio placentae by measurement of PAI-1

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670700
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: KANAYAMA NAOHIRO 浜松医科大学, 医学部, 教授 (70204550)
• Co-Investigator(Kenkyū-buntansha): SUGIHARA Kazuhiro 浜松医科大学, 医学部, 准教授 (00265878) ; YAGUCHI Chiduko 浜松医科大学, 医学部付属病院, 助教 (20397425) ; TAMURA Naoaki 浜松医科大学, 医学部付属病院, 助教 (90402370) ; UCHIDA Toshiyuki 浜松医科大学, 医学部付属病院, 講師 (90570234)
• Research Collaborator: IKUMA Kotomi
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 常位胎盤早期剥離 / 絨毛膜下血腫 / PAI-1 / 切迫流産 / 切迫早産

Outline of Final Research Achievements

Previously we reported that the first report of uncontrollable subchorionic and retroplacental haemorrhage inducing preterm labour in complete PAI-1 deficiency in a human To determine the role of PAI-1 in maintenance of pregnancy, we collected the plasma from 1032 pregnant women in the 1st trimester. The outcome of the pregnancy was examined especially on rate of abortion, preterm delivery and abruptio placentae. The PAI-1 level of abortion with uterine contraction tended to be low compared to normal pregnancy. PAI-1 level was less than 10ng/mL(very low level) in a case out of 3 cases of abruptio placentae. These results suggest that PAI-1 is involved in attachment of feto-maternal interface. We found that PAI-1 staining was weak or absence in the cases of abortion with uterine contraction compared to normal pregnancy.

Free Research Field

産婦人科学