Functional analysis on TrkB signal change in ovarian cancer associated with epithelial mesenchymal transition

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670707
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Tokai University
• Principal Investigator: GOTO Yumiko 東海大学, 医学部, 助教 (50624574)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 卵巣明細胞腺癌 / TrkB / BDNF / アイソフォーム / 上皮間葉転換

Outline of Final Research Achievements

We focused on neurotrophin receptor TrkB which exists abundantly in ovary. We investigated TrkB expression in ovarian cancer and epithelial mesenchymal transition (EMT) signal induced by TrkB. We elucidated that TrkB over expression was observed in ovarian cancer, especially in clear cell adenocarcinoma by immunohistochemistry. We also found that TrkB-Shc and TrkB-T1 isoform which suppress tyrosine kinase signal decreased with advanced stage. We used cell lines of ovarian cancer and we obtained the same founding as above. We will analyse TrkB signal associated with EMT using these cell lines.

Free Research Field

産婦人科