Strategy for the discovery of the candidate genes associated with the age-related macular degeneration and their therapeutic applications

2016 Fiscal Year Final Research Report

• Project/Area Number: 25670733
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Tottori University
• Principal Investigator: BABA Takashi 鳥取大学, 医学部附属病院, 講師 (40304216)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 加齢黄斑変性 / 疾患モデルマウス

Outline of Final Research Achievements

Under the comprehensive analysis of the aqueous humor from the age-related macular degeneration (AMD) patients, the candidate factor X was isolated, which has not been reported the participation in the angiogenesis. The role of the factor X in the pathogenesis of the AMD was investigated with the in vitro analysis using vasucular endothelial cells, the immunohistological analysis using the AMD model mice and the SNP analysis using the genome information from the AMD patients. It was reveled that the choroidal neovascularization (CNV) was inhibited by the blockage of the signal pathway under the factor X and the factor X receptor from the analysis of the AMD models using the knockout mice and the knockdown analysis by the siRNA. It was suggested that the CNVs were modified by the monocytes derived from the bone marrow cells depending on the factor X by the immunohistological analysis with the application of the fluorescein tagged bone marrow cells transplanted mice model.

Free Research Field

眼病理学、眼血管新生、加齢黄斑変性