Metabolomics of cancer tissue -challenge to the paradoxical energy metabolism of cancer cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670786
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Nobuhiro 東北大学, 歯学研究科(研究院), 教授 (60183852)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Tetsu 東北大学, 大学院歯学研究科, 教授 (60226850) ; WASHIO Jumpei 東北大学, 大学院歯学研究科, 助教 (20400260)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 癌 / メタボローム解析 / ワールブルグ効果 / グルタミノリシス

Outline of Final Research Achievements

This study aimed to characterize the metabolic system of oral squamous cell carcinoma (OSCC) by metabolome analysis. The metabolome profiles were obtained from OSCC and its surrounding normal tissues, using CE-TOFMS. Enhancement of glucose consumption and lactate production (Warburg effect) was observed in OSCC tissues, while the downstream intermediates in the glycolysis were decreased and glutamine degradation (glutaminolysis) was enhanced . These results suggest that OSCC tissues supply metabolic intermediates from glucose for biosynthesis via the pentose phosphate cycle and obtain energy from glutamine with lactate production.

Free Research Field

口腔生化学