2015 Fiscal Year Final Research Report
Possibility of bone metabolism improvement by health food with medication
| Project/Area Number |
25670815
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
Akiba Yosuke
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 骨代謝 / 健康食品 / コラーゲンクロスリンク |
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| Outline of Final Research Achievements |
The present study aimed to evaluate the effect of the functional foods for prevention of osteoporosis. We established osteoporosis model rat using ovariectomy operation. Sham operation was used for control. Before or after operation, Functional foods were fed to model animals. Two, 4 and 8 weeks after operation, Tibiae and femurs were collected. Samples were analyzed by micro-CT, three point bending test and Histological staining. Micro-CT images showed that cancellous bone mass in OVX-rats were decreasing from 4 weeks and reached 50% on 8 weeks after operation. Histological sections indicated that bone mineral density and amount of crosslinking were increased in Royal jelly diet and black vinegar diet samples. However, Bone volume and Breaking strength in Royal jelly diet and black vinegar diet samples showed no difference compare to the control.
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| Free Research Field |
歯学
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