2013 Fiscal Year Final Research Report
The effect of stress-related gene expression on nocturnal parafunction.
| Project/Area Number |
25670826
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMOTO Tetsuji 九州歯科大学, 歯学部, 准教授 (30514989)
MASAKI Chihiro 九州歯科大学, 歯学部, 助教 (60397940)
KONDO Yusuke 九州歯科大学, 歯学部, 助教 (00611287)
MUKAIBO Taro 九州歯科大学, 歯学部, 助教 (50635117)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | ストレスマーカー / ベンゾジアゼピン / ブラキシズム / パラファンクション / 睡眠 |
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| Research Abstract |
Peripheral-type benzodiazepine receptor (PBR) gene polymorphism is associated with stress sensitivity, but it is not yet clear whether polymorphisms in this gene have any influence on psychological stress before and after sleep bruxism. The present study was performed to examine the relationship between sleep bruxism and PBR gene polymorphism. The PBR gene was amplified after collection of DNA from oral mucosa cells. Polymorphisms were identified by direct sequencing after PBR gene amplification by PCR. We also measured masseter muscle activity during sleep using portable electromyography to evaluate sleep bruxism. The number of bruxism events was significantly higher in the G/A than the G/G group. Changes in salivary CgA levels were significantly lower in the G/A than G/G group.
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