Therapeutic Interaction of Systemically-administered Mesenchymal Stem Cells with Peri-implant Mucosa

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670833
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Kyushu University
• Principal Investigator: ATSUTA Ikiru 九州大学, 歯学研究科(研究院), 教授 (50195872)
• Co-Investigator(Kenkyū-buntansha): ATSUTA Ikiru 九州大学, 大学院歯学研究院口腔機能修復学講座インプラント・義歯補綴科 (30423487) ; AYUKAWA Yasunori 九州大学, 大学院歯学研究院口腔機能修復学講座インプラント・義歯補綴科 (50304697)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 間葉系幹細胞 / 歯科インプラント治療

Outline of Final Research Achievements

Dental implant therapy is one of the most important prosthodontic therapy options for partially and completely edentulous patients. Dental implants based on the concept of “osseointegration”, a term explaining the fixation of a titanium implant in the bone (Branemark et al., 1983), have shown dramatic continual improvement. However, the peri-implant tissue is always exposed to the possibility of inflammation because the titanium body penetrates into the oral mucosa.Therefore, the improvement of local defense in mucosa is strongly expected to enable successful outcomes in oral implant patients. In this study, we showed that systemic MSC transplantation may be effective for enhancing epithelial sealing around titanium implants.

Free Research Field

補綴学一般