Development of a novel cell and tissue freezing technology using variable magnetic field

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670837
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: KAGAMI Hideaki 松本歯科大学, 歯学部, 教授 (80242866)
• Co-Investigator(Kenkyū-buntansha): SAGARA Hajime 東京大学, 医科学研究所, 助教 (50145041)
• Co-Investigator(Renkei-kenkyūsha): LI Kenki 松本歯科大学, 総合歯科医学研究所, 講師 (60350831)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 凍結保存法 / 凍結生物学 / 細胞 / 再生医療 / 解凍

Outline of Final Research Achievements

For the wide acceptance of regenerative medicine, the development of cell transportation technology is important. However, currently available technologies are not capable to transport living cells for a long distance. Accordingly, freezing is a promissing approach to solve this problem. Tissue engineering utilize cells from patient or donors. Harvesting cells at each treatment is a burden for patients. Cell freezing technology is also beneficial for the stable supply of stem cells. In this study, freezin technology from food industry was introduced and modified to achieve higher living ratio after feeze-thaw cycle. Furthermore, we also investigated the usefulness of direct tissue freezing strategy, which enables cultivation of stem cells from frozen tissue in the future.

Free Research Field

口腔外科学