2014 Fiscal Year Final Research Report
Effect of the cells transformed by elastins on facilitation of DNA/protamine complex-induced bone regeneration
| Project/Area Number |
25670838
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Jun 福岡歯科大学, 歯学部, 講師 (10152208)
MORI Nana 福岡歯科大学, 歯学部, 助教 (60736677)
SHINOZAKI Yosuke 福岡歯科大学, 歯学部, 助教 (80736687)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | エラスチン / ＤＮＡ / プロタミン / 骨再生 / ペースト |
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| Outline of Final Research Achievements |
t was reported that fibroblast cell can differentiate into myofibroblast cell via osetoblast cell in the presence of elaschin peptide. Thus, three mixtures of DNA/protamine complex with salmon-derived water-insoluble elaschin, water-soluble elastin and eraschin peptide were prepared. These pastes were implanted into rat cranial defect for three months. It was found that the DNA/protamine complex with elaschin peptide formed new bone faster than the others. Moreover, real-time PCR indicated that elaschin peptide can facilitate the development of αーSMA and MMP-2. Therefore, elaschin peptide will be useful materials for repair of bone defects.
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| Free Research Field |
生体材料
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