Functional analysis and clinical application of let-7 microRNA in oral cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670844
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: University of Tsukuba
• Principal Investigator: BUKAWA HIROKI 筑波大学, 医学医療系, 教授 (80173558)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: microRNA / let-7 / 口腔がん / 腫瘍生物学

Outline of Final Research Achievements

We revealed that let-7c microRNA and the let-7g microRNA expression is significantly reduced as compared to normal tissue in the oral cancer tissue. Furthermore we also revealed that the expression of let-7c and let-7g is significantly reduced as compared to normal skin cell lines in cell line (HSC3) derived human oral carcinoma. In addition, we made it clear that the expression level of these two microRNA is correlated with cervical lymph node metastasis of oral cancer. Finally we have found that the addition of an agonist of the let-7c and let-7g to HSC3 may inhibit cancer cell growth ability.

Free Research Field

口腔がんにおけるmicroRNAを対象とした腫瘍生物学