development of functional regenerative bone as a stem cell reserver

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670847
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: HOSHI Kazuto 東京大学, 医学部附属病院, 准教授 (30344451)
• Co-Investigator(Kenkyū-buntansha): FUJIHARA Yuko 東京大学, 医学(系)研究科(研究院), 特任助教 (50466744) ; MORI Yoshiyuki 自治医科大学, 医学部, 教授 (70251296) ; TAKATO Tsuyoshi 東京大学, 医学部附属病院, 教授 (90171454)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ステムセル・レザバー / 間葉系幹細胞 / 造血幹細胞 / 骨再生 / 再生医療

Outline of Final Research Achievements

For development of functional regenerative bone as a stem cell reserver, we examined the factor to maintain a mesenchymal stem cells and hematopoietic stem cells in rhBMP-2-induced regenerative bone, and its optimal dose. Based on this condition, we prepared a scaffold containing the factor to maintain hematopoietic stem cells within it, and also made a prototype of functional regenerative bone enclosing the rhBMP-2 into the scaffold, Finally, we established manufacturing condition of functional regenerative bone through animal experimental models using mice or others.

Free Research Field

医歯薬学