Development of new therapeutic method of novel influenza by the promotion of salivary protein synthesis and secretion by PDE

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670855
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Mie University
• Principal Investigator: MURATA TAKU 三重大学, 医学部附属病院, 講師 (80242965)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Kasumi 三重大学, 医学部附属病院, 助教 (20378368)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 唾液腺 / cAMP / phosphodiesterase

Outline of Final Research Achievements

There is possibility of the explosion infection (pandemic) by the mutation of avian influenza virus. Therefore, we studied relationship between phosphodiesterase (PDE) and antivirus salivary proteins. As the sublingual gland does not have action of the adrenergic nerve, we had thought that there was little PDE activity in the sublingual gland. However, the PDE activity in the sublingual gland was like other salivary glands. And it was suggested that there was the specific PDE action in the sublingual gland. In submandibular acini cells, PDE3 inhibitor stimulated the expressions of amylase and aquaporin. We did not found the difference knockout and wild mouse in the further detailed studies.

Free Research Field

医歯薬学