2015 Fiscal Year Final Research Report
Application of boron carbide particles to boron neutron capture therapy
Project/Area Number |
25670857
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Osaka University |
Principal Investigator |
YURA YOSHIAKI 大阪大学, 歯学研究科(研究院), 教授 (00136277)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 口腔扁平上皮癌 / 中性子 / ホウ素化合物 / 炭化ホウ素球 / 超音波照射 / 溶媒 |
Outline of Final Research Achievements |
Boronophenylalanine (BPA)is a major boron compound used in boron neutron capture therapy (BNCT)for cancer patients. Boron-rich boron carbide (B4C) nanoparticles are novel compounds containing a large number of born molecules. The tumor volume was smaller in B4C-mediated BNCT group than in neutron group. Purebright MB was found to solubilize B4C particles. This suggests that B4C particles injected intratumorally act as boron compounds for BNCT.
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Free Research Field |
口腔外科学
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