Differentiation therapy of oral cancer by inhibiting deubiquitinase of Id protein

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670860
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: MURASE RYUICHI 愛媛大学, 医学部附属病院, 講師 (70452696)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: Id / 脱ユビキチン化酵素 / USP-1 / 分化誘導療法

Outline of Final Research Achievements

The transcriptional factor Id is known to regulate several malignant phenotypes in oral cancers. In this study, we revealed that the expression of Id is mainly mediated by certain types of deubiquitinating enzymes, and that USP-1, known as one of deubiquitinases, promotes cell proliferation and invasion. Downregulation of USP-1 suppressed Id expression, which directly lead to tumor suppression in in vivo experiments. These results suggest that a certain type of deubiquitinases, which potentially modulate transcripitional factors, might be established as a novel therapeutic method for oral cancer patients.

Free Research Field

口腔癌