Mechanism of aggravation of periodontitis caused by periodontitis-related bacteria transmitted from companion animals

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670873
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Osaka University
• Principal Investigator: NOMURA Ryota 大阪大学, 歯学研究科(研究院), 准教授 (90437385)
• Co-Investigator(Kenkyū-buntansha): NAKANO Michiyo 岡山大学, 医歯(薬)学総合研究科, 教授 (30359848) ; ASAI Fumitoshi 麻布大学, 獣医学部, 教授 (00511677)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 歯周病原性細菌 / 伴侶動物 / Porphyromonas gulae / 犬 / FimA / 僧帽弁閉鎖不全症 / 線毛型 / 伝播

Outline of Final Research Achievements

Information regarding transmission of periodontitis-related bacterial species between dogs and their owners is limited. In the present study, we detected periodontitis-related species in both dogs and their owners including Porphyromonas gulae, known to be a major bacterial pathogen of periodontitis in dogs. P. gulae possesses approximately 41-kDa filamentous appendages (FimA), which have been classified into three major genotypes; A, B, and C. Our results showed that P. gulae with FimA genotype C was associated with mitral regurgitation in dogs.

Free Research Field

歯学