2014 Fiscal Year Final Research Report
New hypothesis for the pathogenesis of periodontal medicine
| Project/Area Number |
25670882
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Tomoyuki 新潟大学, 医歯学総合病院, 医員 (30447635)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Shota 大阪大学, 微生物病研究所, 助教 (90432434)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 歯周病 / 全身疾患 / 腸内細菌叢 |
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| Outline of Final Research Achievements |
We revealed that oral adinistration of P. gingivalis induced the inflammatory changes in the adipose tissue, liver, and gut. These chages were associated with insulin resistance. Furthermore, oral administration of P. gingivalis induced an alteration of the gut microbiota, a decreased gut barrier function, and an elevation of blood endotoxin levels in a mouse model. Our study showing that swallowing large amounts of oral bacteria alters the gut microbiota provides a rationale for the biological basis of a causal association between periodontal disease and systemic diseases.
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| Free Research Field |
歯周病学
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